University of Virginia Health System researchers found that two interacting genes related to bitter taste sensitivity play an important role in a person’s development of nicotine dependence and smoking behavior. People with higher taste sensitivity aren’t as likely to become dependant on nicotine as people with decreased taste sensitivity, the researchers discovered.

Newswise — Could an aversion to bitter substances or an overall heightened sense of taste help protect some people from becoming addicted to nicotine? That’s what researchers at UVA have found using an innovative new method they’ve developed to analyze the interactions of multiple genetic and environmental factors. Their findings one day may be key in identifying people at risk for nicotine dependence.

In a study published in the October 10, 2008 issue of The American Journal of Human Genetics, University of Virginia Health System researchers report that two interacting genes related to bitter taste sensitivity, TAS2R16 and TAS2R38, play an important role in a person’s development of nicotine dependence and smoking behavior. Researchers found that people with higher taste sensitivity aren’t as likely to become dependant on nicotine as people with decreased taste sensitivity.

“This new knowledge is an important tool in predicting whether a person is likely to become a smoker or not,” says lead investigator Ming Li, Ph.D., professor of psychiatry and behavioral neurosciences who specializes in addiction and genetics research.

It’s long been known that a person’s ability to taste bitter substances plays a crucial role in the rejection of potentially toxic foods, but taste sensitivity varies widely among individuals and between ethnic groups. Previous studies have suggested a link between so-called taster status and nicotine dependence, but genetic evidence underlying such a link has been lacking.

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